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Belvarafenib

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SI-6512

Belvarafenib, >98% (HPLC)

CAS No. : [1446113-23-0]

Synonyms : HM-95573; GDC-5573; RG-6185

IUPAC Name : 4-Amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Properites
Mol. Formula :
C23H16ClFN6OS
Mol. Weight :
478.93
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Belvarafenib inhibits B‑RAF (IC50 = 56 nM), B‑RAF^V600E (IC50 = 7 nM), and C‑RAF (IC50 = 5 nM), demonstrating potent pan‑RAF activity relevant to studies of MAPK signaling and RAF‑dependent oncogenic pathways.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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