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Belzutifan-(S,S,S)-isomer

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Belzutifan-(S,S,S)-isomer, >98%

CAS No. : [1672668-51-7]

IUPAC Name : 3-(((1S,2S,3S)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile

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Chemical Properites
Mol. Formula :
C17H12F3NO4S
Mol. Weight :
383.34
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an isomer of Belzutifan, which is an orally active and selective HIF-2α inhibitor. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is used for the treatment of clear cell renal cell carcinoma (ccRCC).

References : Xu R. et al.: J. Med Chem., 62(15), 6876-6893, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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