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Belzutifan trifluoro impurity

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Belzutifan trifluoro impurity, >98%

CAS No. : [2738682-44-3]

IUPAC Name : 3-Fluoro-5-(((1R,2R,3R)-1,2,3-trifluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

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Chemical Properites
Mol. Formula :
C17H11F4NO3S
Mol. Weight :
385.33
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Belzutifan, which is an orally active and selective HIF-2α inhibitor. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is used for the treatment of clear cell renal cell carcinoma (ccRCC).

References : Xu R. et al.: J. Med Chem., 62(15), 6876-6893, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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