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Bendamustine-d8

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SL-7236

Bendamustine-d8, >98%

Isotopic Purity : 98 atom % D

CAS No. : [1185068-23-8]

Synonyms : EP-3101-d8; SDX-105-d8

IUPAC Name : 4-(5-(Bis(2-chloroethyl-d4)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride

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Chemical Properites
Mol. Formula :
C16H13D8Cl2N3O2 . HCl
Mol. Weight :
402.77
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Bendamustine-d8 is a deuterium labelled version an analog of Bendamustine, which is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. It is used as an anticancer drug.

References : Leoni L. M. et al.: Clin Cancer Res., 14(1), 309-317, 2008; Cives M. et al.: Cell Signal., 25(5), 1108-1117, 2013; Ackler S. et al.: Br. J . Pharmacol., 167(4), 881-891, 2012; Minbo Zang et al.: J. Biomed Res., 1-12, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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