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Bendamustine ethyl ester

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Bendamustine ethyl ester, >98%

CAS No. : [87475-54-5]

IUPAC Name : Ethyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

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Chemical Properites
Mol. Formula :
C18H25Cl2N3O2
Mol. Weight :
386.32
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : Bendamustine ethyl ester is an impurity of Bendamustine, which is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. It is used as an anticancer drug.

References : Leoni L. M. et al.: Clin Cancer Res., 14(1), 309-317, 2008; Cives M. et al.: Cell Signal., 25(5), 1108-1117, 2013; Ackler S. et al.: Br. J . Pharmacol., 167(4), 881-891, 2012; Minbo Zang et al.: J. Biomed Res., 1-12, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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