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Benidipine-d7

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SL-9298

Benidipine-d7, >98%

Related CAS No. : [105979-17-7] of the unlabelled compound

IUPAC Name : rel-3-Methyl 5-((R)-1-((phenyl-d5)methyl-d2)piperidin-3-yl) (R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Properites
Mol. Formula :
C28H24D7N3O6
Mol. Weight :
512.61
Appearance :
Yellow solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Benidipine, which is a potent, orally administered calcium channel antagonist. Benidipine demonstrates anti-apoptotic properties in ischaemic or reperfused myocardial cells. Additionally, Benidipine enhances the activity of endothelial cell-type nitric oxide synthase and contributes to improved coronary circulation in hypertensive rat models.

References : Yao K. et al.: J. Pharmacol Sci., 100(4), 243-61, 2006; Gao F. et al.: Br. J. Pharmacol., 132(4), 869-78, 2001; Kobayashi N. et al.: Am. J. Hypertens 12(5), 483-91, 1999; Masanori S. et al.: Circ J. 68(3), 241-6, 2004.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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