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BGT226

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SI-5322

BGT226, >98% (HPLC)

CAS No. : [915020-55-2]

MDL No. : MFCD22376639

Synonyms : NVP-BGT226

IUPAC Name : 8-(6-Methoxypyridin-3-yl)-3-methyl-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

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Chemical Properites
Mol. Formula :
C28H25F3N6O2
Mol. Weight :
534.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BGT226 is a novel class I PI3K/mTOR dual inhibitor. BGT226 displays potent growth-inhibitory activity against human head and neck cancer cells.

References : Markman B. et al.: Ann Oncol., 23(9), 2399-2408, 2012; Chang K. Y. et al.: Clin Cancer Res., 17(22), 7116-7126, 2011; Baumann P. et al.: Anticancer Drugs, 23(1), 131-138, 2012; Glienke W. et al.: Tumour Biol., 33(3), 757-765, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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