BI-0474

SI-8128

BI-0474, >98% (HPLC)

CAS No. : [2750570-55-7]

IUPAC Name : (S)-4-(3-(4-(4-Acryloylpiperazin-1-yl)-6-((S)-2,4-dimethylpiperazin-1-yl)pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BI‑0474 is a potent KRAS^G12C inhibitor that blocks the GDP‑KRAS::SOS1 protein–protein interaction with an IC₅₀ of 7.0 nM. It shows strong antiproliferative activity in NCI‑H358 (G12C) mutant cells and demonstrates robust antitumor efficacy in non‑small cell lung cancer xenograft models, highlighting its value as a KRAS^G12C‑targeted tool compound for oncology research.

References : Broker J. et al.: J Med Chem., 65(21), 14614-14629, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.