BI-3406

SI-6636

BI-3406, >98% (HPLC)

CAS No. : [2230836-55-0]

IUPAC Name : N-((R)-1-(3-Amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BI‑3406 potently inhibits the KRAS–SOS1 interaction (IC₅₀ = 6 nM), leading to reduced KRAS‑GTP loading and suppression of MAPK pathway activation. Its robust inhibition of RAS‑dependent signaling underlies its demonstrated anticancer efficacy.

References : Hofmann H. M. et al.: Mol. Cancer Ther., 18 (12_Supplement), PL06-01, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.