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Binimetinib-d4

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SL-9311

Binimetinib-d4, >98%

CAS No. : [2890696-60-1]

Synonyms : MEK162-d4; ARRY-162-d4; ARRY-438162-d4

IUPAC Name : 5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy-1,1,2,2-d4)-1-methyl-1H-benzo[d]imidazole-6-carboxamide

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Chemical Properites
Mol. Formula :
C17H11D4BrF2N4O3
Mol. Weight :
445.26
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Binimetinib, which is an oral and selective MEK1/2 inhibitor. Binimetinib has potential to treat various cancers.

References : Serra V. et al.: J. Clin Invest., 123(6), 2551-2563, 2013; Kiessling M. K. et al.: Oncotarget., 6(39), 42183-96, 2015; Cheng H. et al.: Oncogene 35(23), 2961-70, 2016; Seip K. et al.: Oncotarget., 7(15), 19997-20015, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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