Bisindolylmaleimide IX

SL-1187

Bisindolylmaleimide IX, >98%

CAS No. : [138489-18-6]

MDL No. : MFCD03788207

Synonyms : RO 31-8220 methanesulfonate salt; RO 31-8220 mesylate

IUPAC Name : 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate salt

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Applications : RO 31-8220 mesylate is a protein kinase C inhibitor, with activity at other protein kinases (IC₅₀ values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range.

References : Davies S. P. et al.: Biochem. J. 351, 95,2000; Lingameneni R. et. al.: FEBS Lett. 473, 265, 2000; Standaert M. L. et al.: Endocrinology 150, 2145,1999; Mou H. et al.: Cell Stem Cell 19, 217, 2016.

Storage : Keep container tightly closed under nitrogen or argon and store at -20^oC for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.