Bisindolylmaleimide IX-d3

SL-1188

Bisindolylmaleimide IX-d₃, >97% (CP)

Isotopic Purity : 99 atom % D

Related CAS No. : [138489-18-6] of the unlabelled compound

Synonyms : RO 31-8220 methanesulfonate-d₃; RO 31-8220 mesylate-d₃

IUPAC Name : 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methyl-d₃ indol-3-yl)maleimide methanesulfonate salt

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
10MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
25MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026

Applications : This is a deuterium labelled version of RO 31-8220 mesylate, which is a protein kinase C inhibitor, with activity at other protein kinases (IC₅₀ values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range.

References : Davies S. P. et al.: Biochem. J. 351, 95, 2000; Lingameneni R. et. al.: FEBS Lett. 473, 265, 2000; Standaert M. L. et al.: Endocrinology 150, 2145, 1999; Mou H. et al.: Cell Stem Cell 19, 217, 2016.

Storage : Keep container tightly closed under nitrogen or argon and store at -20^oC for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.