BLU-945

SI-7828

BLU-945, >98% (HPLC)

CAS No. : [2660250-10-0]

Synonyms : ZL-2313

IUPAC Name : N-(2-((3S,4R)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)-5-isopropyl-8-((2R,3S)-2-methyl-3-((methylsulfonyl)methyl)azetidin-1-yl)isoquinolin-3-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BLU‑945 is a reversible, mutant‑selective EGFR inhibitor with strong activity against L858R, exon 19 deletion, T790M, and C797S mutations. Its ability to suppress multiple resistance‑driving EGFR variants supports its use in NSCLC and other EGFR‑dependent lung‑cancer models.

References : Eno S. M. et al.: J. Med. Chem., 65(14), 9662-9677, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.