BMS-1166

SI-6546

BMS-1166, >98% (HPLC)

CAS No. : [1818314-88-3]

IUPAC Name : (2R,4R)-1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BMS‑1166 disrupts the PD‑1/PD‑L1 interaction with nanomolar potency (IC₅₀= 1.4 nM) by inducing PD‑L1 dimerization and blocking PD‑1 binding. This leads to effective antagonism of PD‑1/PD‑L1‑driven T‑cell suppression, supporting its use in immuno‑oncology research.

References : Guzik K. et al.: J. Med. Chem., 60(13), 5857-5867, 2017; Skalniak L. et al.: Oncotarget, 8(42), 72167-72181, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.