BMS-1166-N-piperidine-CO-N-piperazine

SI-6548

BMS-1166-N-piperidine-CO-N-piperazine, >98% (HPLC)

CAS No. : [2447066-14-8]

IUPAC Name : 3-((4-Chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((2-(piperazine-1-carbonyl)piperidin-1-yl)methyl)phenoxy)methyl)benzonitrile

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25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : BMS‑1166‑N‑piperidine‑CO‑N‑piperazine is a PROTAC‑ready BMS‑1166 derivative used to generate PD‑1/PD‑L1 degrader‑1 (IC₅₀ = 39.2 nM). Its dihydrochloride salt provides better solubility and stability than the free form.

References : Cheng B. et al.: Eur. J. Med. Chem., 199, 112377, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.