BMS-1166-N-piperidine-COOH

SI-6547

BMS-1166-N-piperidine-COOH, >98% (HPLC)

CAS No. : [2447066-00-2]

IUPAC Name : 1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BMS‑1166‑N‑piperidine‑COOH is a BMS‑1166–derived PROTAC building block used to generate PD‑1/PD‑L1 degrader‑1. BMS‑1166 itself is a potent PD‑1/PD‑L1 inhibitor (IC₅₀= 1.4 nM) that restores T‑cell activation.

References : Binbin Cheng et al.: Eur. J. Med. Chem., 199, 112377, 2020; Guzik K. et al.: J. Med. Chem., 60(13), 5857-5867, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.