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SI-7194

BMS-5, >98% (HPLC)

CAS No. : [1338247-35-0]

IUPAC Name : N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide

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Chemical Properites
Mol. Formula :
C17H14Cl2F2N4OS
Mol. Weight :
431.28
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BMS‑5 selectively inhibits LIMK1 and LIMK2 with low‑nanomolar potency (IC50 = 7/8 nM), making it a valuable tool for studying LIMK‑mediated actin dynamics and related cellular processes.

References : Ross-Macdonald P. et al.: Mol. Cancer Ther., 7(11), 3490-8, 2008;
Petrilli A. et al.: Oncogene, 33(27), 3571-82, 2014; Lunardi P. et al.: Mol. Neurobiol., 55(2), 958-967, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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