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BMS-536924

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SI-6608

BMS-536924, >98% (HPLC)

CAS No. : [468740-43-4]

IUPAC Name : (S)-4-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

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Chemical Properites
Mol. Formula :
C25H26ClN5O3
Mol. Weight :
479.97
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BMS‑536924 selectively and competitively inhibits IGF‑1R and IR with low‑nanomolar potency, blocking key signaling pathways involved in proliferation and survival. Its strong oral activity and anti‑cancer effects make it a valuable tool for studying IGF‑1R/IR‑mediated oncogenic mechanisms.

References : Wittman M. et al.: J. Med. Chem., 48(18), 5639-43, 2005; Litzenburger B. C. et al.: Clin. Cancer Res., 15(1), 226-37, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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