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BMS-833923

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SI-5489

BMS-833923, >98% (HPLC)

CAS No. : [1059734-66-5]

MDL No. : MFCD25976660

IUPAC Name : N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide

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Chemical Properites
Mol. Formula :
C30H27N5O
Mol. Weight :
473.58
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BMS-833923 is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.

References : Tang J. Y. et al.: Semin Cutan Med Surg., 30(4 Suppl), S14-18, 2011; Zaidi A. H. et al.: Cancer Invest., 31(7), 480-489, 2013; Wilkinson S. E. et al. Prostate., 73(16), 1810-1823., 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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