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BMS-986020

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SI-7645

BMS-986020, >98% (HPLC)

CAS No. : [1257213-50-5]

Synonyms : AM-152

IUPAC Name : (R)-1-(4'-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

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Chemical Properites
Mol. Formula :
C29H26N2O5
Mol. Weight :
482.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BMS‑986020 selectively blocks LPA1 with high affinity and also inhibits BSEP, MRP4, and MDR3 transporters at micromolar concentrations (IC50 = 4.8–7.5 µM). Its ability to modulate LPA1‑driven fibrotic signaling supports its potential application in idiopathic pulmonary fibrosis research and therapy development.

References : Kihara Y. et al.: Exp. Cell. Res., 333(2), 171-7, 2015; Palmer S. M. et al.: Chest., 154(5), 1061-1069, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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