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BMS-986142

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SI-6290

BMS-986142, >98% (HPLC)

CAS No. : [1643368-58-4]

IUPAC Name : (2S)-6-Fluoro-5-(3-(8-fluoro-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-2-methylphenyl)-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide

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Chemical Properites
Mol. Formula :
C32H30F2N4O4
Mol. Weight :
572.61
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BMS‑986142 is a reversible and highly selective BTK inhibitor with robust sub‑nanomolar potency (IC50 = 0.5 nM), making it a valuable tool for probing BTK‑dependent signaling in immune‑mediated diseases.

References : Watterson S. H. et al.: J. Med. Chem., 59(19), 9173-9200, 2016; Kathleen M. Gillooly. et al.: PLoS One., 12(7), e0181782, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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