BMS-986202

SI-6278

BMS-986202, >98% (HPLC)

CAS No. : [1771691-34-9]

IUPAC Name : 6-(Cyclopropanecarboxamido)-4-((3-(5-fluoropyrimidin-2-yl)-2-methoxyphenyl)amino)-N-(methyl-d3)nicotinamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BMS‑986202 binds the TYK2 JH2 pseudokinase domain with sub‑nanomolar potency (IC₅₀ = 0.19 nM; K_i = 0.02 nM) and displays exceptional selectivity over JAK family kinases. It is a weak CYP2C19 inhibitor and demonstrates strong efficacy in preclinical models of IL‑23‑mediated skin inflammation, anti‑CD40‑induced colitis, and spontaneous lupus. It is a de novo deuterated analogue.

References : Liu C. et al.: J. Med. Chem. 64(1), 677-694, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.