BMS-986251

SI-6606

BMS-986251, >98% (HPLC)

CAS No. : [2460133-35-9]

IUPAC Name : (1R,3S,4R)-4-((3aR,9bR)-9b-((4-Fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BMS‑986251 selectively targets RORγt with nanomolar potency (EC₅₀ = 12 nM) and suppresses IL‑17 production in human whole blood (EC₅₀ = 24 nM). It demonstrates robust activity in mouse acanthosis and imiquimod‑induced psoriasis models, highlighting its value for probing Th17‑mediated inflammatory pathways.

References : Cherney R. J. et al.: ACS Med. Chem. Lett., 11(6), 1221-1227, 2020; Haggerty H. G. et al.: Toxicol Sci.,183(1), 93-104, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.