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BNC375

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SI-5671

BNC375, >98% (HPLC)

CAS No. : [1557240-80-8]

IUPAC Name : 4-((1R,3R)-3-(((5-Chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)benzenesulfonamide

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Chemical Properites
Mol. Formula :
C19H23ClN2O3S
Mol. Weight :
394.91
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BNC375 is a potent, selective, and orally available type I positive allosteric modulator (PAM) of α7 nAChRs with an EC50 of 1.9 μM. BNC375 exhibits good CNS-drug like properties and potential clinical candidate.

References : Harvey J. A. et al.: ACS Med Chem Lett., 10(5), 754-760, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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