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Boc-Trilaciclib DBU salt

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Boc-Trilaciclib DBU salt, >98%

IUPAC Name : tert-Butyl 2'-chloro-5'-hydroxy-6'-oxo-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidine]-7'(8'H)-carboxylate--2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine (1/1)

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Chemical Properites
Mol. Formula :
C19H23ClN4O4 • C9H16N2
Mol. Weight :
559.11
Appearance :
Dark orange solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the synthesis of Trilaciclib and related analogs. Trilaciclib is an oral CDK4/6 inhibitor. It effectively suppresses tumour cell proliferation and helps reduce the blood-related toxicity associated with chemotherapy. Additionally, Trilaciclib lessens both apoptosis and myelosuppression caused by 5-Fluorouracil (5-FU) chemotherapy.

References : Bisi J. E. et al.: Mol Cancer Ther., 15(5), 783-93, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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