Boc-Trilaciclib impurity

SL-11778

Boc-Trilaciclib impurity, >98%

CAS No. : [2170791-57-6]

Synonyms : Spiro[cyclohexane-1,9′(6′H)-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidine]-7′(8′H)-carboxylic acid, 2′-chloro-6′-oxo-, 1,1-dimethylethyl ester

IUPAC Name : tert-Butyl 2'-chloro-6'-oxo-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidine]-7'(8'H)-carboxylate

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Applications : This is an impurity of Trilaciclib, which is an oral CDK4/6 inhibitor that effectively suppresses tumour cell proliferation and helps reduce the blood-related toxicity associated with chemotherapy. Additionally, Trilaciclib lessens both apoptosis and myelosuppression caused by 5-Fluorouracil (5-FU) chemotherapy.

References : Bisi J. E. et al.: Mol Cancer Ther., 15(5), 783-93, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.