Bortezomib impurity 36

SL-7310

Bortezomib impurity 36, >98%

CAS No. : [114457-94-2]

IUPAC Name : (Pyrazine-2-carbonyl)-L-phenylalanine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
1G	10.00		Back Order	Estimated to ship on 20 September 2026
5G	12.00		Back Order	Estimated to ship on 20 September 2026
25G	45.00		Back Order	Estimated to ship on 20 September 2026
100G	155.00		Back Order	Estimated to ship on 20 September 2026

Applications : This is an impurity of Bortezomib, which is a potent 20S proteasome inhibitor. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

References : Adams J. et al.: Cancer Res., 59(11), 2615-2622, 1999; Boccadoro M. et al.: Cancer Cell Int., 5(1), 18, 2005; LeBlanc R. et al.: Cancer Res., 62(17), 4996-5000, 2002; Stein R. L. et al.: Biochemistry 35(13), 3899-3908, 1996; Hideshima T. et al.: Cancer Res., 61(7), 3071-3076, 2001, Mohammad A. Shahshahan et al.: Am J. Cancer Res., 1(7), 913-24,2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.