Bortezomib impurity F

SL-7315

Bortezomib impurity F, >98%

CAS No. : [73058-37-4]

MDL No. : MFCD26405755

IUPAC Name : Methyl (pyrazine-2-carbonyl)-L-phenylalaninate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
1G	Request A Quote		Back Order	Estimated to ship on 04 October 2026
5G	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is an impurity of Bortezomib, which is a potent 20S proteasome inhibitor. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

References : Adams J. et al.: Cancer Res., 59(11), 2615-2622, 1999; Boccadoro M. et al.: Cancer Cell Int., 5(1), 18, 2005; LeBlanc R. et al.: Cancer Res., 62(17), 4996-5000, 2002; Stein R. L. et al.: Biochemistry 35(13), 3899-3908, 1996; Hideshima T. et al.: Cancer Res., 61(7), 3071-3076, 2001, Mohammad A. Shahshahan et al.: Am J. Cancer Res., 1(7), 913-24, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.