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Bosentan USP related compound C

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Bosentan USP related compound C, >98% (HPLC)

CAS No. : [1097263-60-9]

MDL No. : MFCD25977342

Synonyms : Bosentan dimer impurity

IUPAC Name : N,N’-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2’-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide

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Chemical Properites
Mol. Formula :
C52H52N10O10S2
Mol. Weight :
1041.16
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Bosentan, which is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors.

References : Dhillon S. et al.: Am J. Cardiovasc Drugs 9(5), 331-350, 2009; Akamata K. et al.: Arthritis Res Ther. 16(2), R86, 2014; Iglarz M. et al.: Life Sci. 118(2), 333-339, 2014; Son G. Y. et al.: PLoS One 11(12), e0167713, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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