Bosutinib

SL-1186

Bosutinib, >98%

CAS No. : [380843-75-4]

MDL No. : MFCD07367846

IUPAC Name : 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
1G	95.00		Back Order	Estimated to ship on 04 October 2026
5G	295.00		Back Order	Estimated to ship on 04 October 2026
10G	455.00		Back Order	Estimated to ship on 04 October 2026
25G	955.00		Back Order	Estimated to ship on 04 October 2026

Applications : Bosutinib is a dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.

References : Boschelli D. H. et. al.: J. Med. Chem. 44(23), 3965, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.