BP-44

SI-7058

BP-44, >98% (HPLC)

IUPAC Name : 6,7-Dimethoxy-2-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)quinazolin-4(3H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : BP‑44 is a selective dual BRD4–PARP1 inhibitor that suppresses homologous recombination in triple‑negative breast cancer (TNBC), triggering synthetic lethality and inducing cell‑cycle arrest and DNA damage. It shows strong activity in BRCA‑competent TNBC models, representing an optimized BRD4–PARP1 chemotype with potential as a future therapeutic candidate. This strategy expands the applicability of PARP inhibition to BRCA‑proficient TNBC, addressing a key unmet need in oncology.

References : Zhang J. et al.: J. Med. Chem., 65(9), 6803-6825, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.