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Bradanicline

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SI-5663

Bradanicline, >98% (HPLC)

CAS No. : [639489-84-2]

Synonyms : TC-5619

IUPAC Name : N-((2S,3R)-2-(Pyridin-3-ylmethyl)quinuclidin-3-yl)benzofuran-2-carboxamide

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Chemical Properites
Mol. Formula :
C22H23N3O2
Mol. Weight :
361.45
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline is used for the research of cognitive disorders.

References : Mazurov A. A. et al.: J. Med Chem., 55(22), 9793-9809, 2012; Hauser T. A. et al.: Biochem Pharmacol., 78(7), 803-812, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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