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Branebrutinib

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SI-3828

Branebrutinib, >98% (HPLC)

CAS No. : [1912445-55-6]

MDL No. : MFCD31631584

Synonyms : BMS-986195

IUPAC Name : (S)-4-(3-(But-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

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Chemical Properites
Mol. Formula :
C20H23FN4O2
Mol. Weight :
370.42
Appearance :
White solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Branebrutinib is a potent, covalent, irreversible inhibitor of bruton’s tyrosine kinase (BTK), with an IC50 of <1 nM. Branebrutinib is currently being evaluated in clinical trials for various autoimmune inflammatory disorders, including rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren's syndrome, and atopic dermatitis.

References : Watterson H. S. et al.: J. Med. Chem., 62(7), 3228−3250, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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