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Brequinar

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SI-4954

Brequinar, >98% (HPLC)

CAS No. : [96187-53-0]

MDL No. : MFCD00866437

Synonyms : NSC 368390; DUP785

IUPAC Name : 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; 6-Fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid

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Chemical Properites
Mol. Formula :
C23H15F2NO2
Mol. Weight :
375.37
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Brequinar is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), with potent activities against a broad spectrum of viruses.

References : Knecht. W. et al.: Biochem. Pharmacol., 56, 1259-1264, 1998; Lucas-Hourani M. et al.: J. Med. Chem., 58(14), 5579-5598, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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