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Brivanib alaninate

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SI-6733

Brivanib alaninate, >98% (HPLC)

CAS No. : [649735-63-7]

Synonyms : (R)-Brivanib alaninate; BMS-582664

IUPAC Name : (S)-1-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl D-alaninate

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Chemical Properites
Mol. Formula :
C22H24FN5O4
Mol. Weight :
441.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Brivanib alaninate selectively inhibits VEGFR2 with an IC50 of 25 nM and retains moderate inhibitory activity against VEGFR1 and FGFR1. Its kinase profile includes >240‑fold selectivity relative to PDGFRβ, supporting its use in angiogenesis‑related research.

References : Bhide R. S. et al.: J. Med. Chem., 49 (7), 2143-2146, 2006; Nakamura I. et al.: PLoS One., 10(11), e0142355, 2015; Huynh H. et al.: Clin. Cancer Res. 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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