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BTZ043

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SI-5919

BTZ043, >98% (HPLC)

CAS No. : [1161233-85-7]

MDL No. : MFCD17215196

IUPAC Name : (S)-2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one

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Chemical Properites
Mol. Formula :
C17H16F3N3O5S
Mol. Weight :
431.39
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), for the potential treatment of tuberculosis (TB).

References : Makarov V. et al.: Antimicrob Agents Chemother., 59(8), 4446-4452, 2015;
Makarov V. et al.: Science 324(5928), 801-4, 2009; Alejandra N. et al. PLoS Negl Trop Dis., 9(10), e0004022, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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