BY-27

SI-7328

BY-27, >98% (HPLC)

CAS No. : [2247236-59-3]

IUPAC Name : (R)-N-(4-Chlorophenyl)-1-methyl-8-(1-methyl-1H-pyrazol-4-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a]azepin-6-amine

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Applications : BY-27 selectively targets the BD2 domains of BET proteins with pronounced BD1/BD2 selectivity (38‑fold for BRD2, 5‑fold for BRD3, 7‑fold for BRD4, and 21‑fold for BRDT). It exhibits notable anticancer activity, making it a valuable tool for studying BD2‑driven oncogenic signaling.

References : Chen D. et al.: Eur. J. Med. Chem., 182, 111633, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.