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Cabozantinib N-oxide

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Cabozantinib N-oxide, >98%

CAS No. : [1621681-63-7]

IUPAC Name : 4-(4-(1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6,7-dimethoxyquinoline 1-oxide

Price And Availability
Pack SizePrice in USDAdd To Shopping CartAvailabilityShipping Status
100MG395.00
In Stock  Estimated to ship on 20 September 2026
250MG665.00
In Stock  Estimated to ship on 20 September 2026
1G1795.00
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C28H24FN3O6
Mol. Weight :
517.51
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : 2-Hydroxy cabozantinib is an impurity of Cabozantinib, which is an inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. It is used to treat medullary thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma.

References : You W. K. et al.: Cancer Res., 71(14), 4758-4768, 2011; Torres K. E. et al.: Clin Cancer Res., 17(12), 3943-3955, 2011; Yakes F. M. et al.: Mol Cancer Ther., 10(12), 2298-2308, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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