Captopril EP impurity B

SI-5783

Captopril EP impurity B, >98% (HPLC)

CAS No. : [80629-35-2]

MDL No. : MFCD27966950

IUPAC Name : ((S)-3-Bromo-2-methylpropanoyl)-L-proline

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : This is an impurity of Captopril (Captopril EP impurity B), which is an antihypertensive agent. A thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM.

References : Afrin S. et al.: J. Agric Food Chem., 64(11), 2263-2268, 2016; Esmaeili S. et al.: Chem Biol Interact., 265, 24-35, 2017; Li N. et al.: Bioorg Med Chem Lett., 24(1), 386-389, 2014; Tzakos A. G. et al.: Bioorg Med Chem Lett, 16(19), 5084-7, 2006; Song J. C. et al.: Clin Pharmacokinet., 41(3), 207-24, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.