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Captopril EP impurity O

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SI-5792

Captopril EP impurity O, >98% (HPLC)

IUPAC Name : (2'S)-((2S,2'S)-3,3'-(Propane-2,2-diylbis(sulfanediyl))bis(2-methylpropanoyl))di-L-proline

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5MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Note: SI-5792 is not in stock but can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and Mass analysis. Purity (HPLC) is usually >98%. COA, QC data and SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or Request A Quote. We respond promptly. Thank You!
Chemical Properites
Mol. Formula :
C21H34N2O6S2
Mol. Weight :
474.63
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Captopril (Captopril EP impurity O), which is an antihypertensive agent. A thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM.

References : Afrin S. et al.: J. Agric Food Chem., 64(11), 2263-2268, 2016; Esmaeili S. et al.: Chem Biol Interact., 265, 24-35, 2017; Li N. et al.: Bioorg Med Chem Lett., 24(1), 386-389, 2014; Tzakos A. G. et al.: Bioorg Med Chem Lett, 16(19), 5084-7, 2006; Song J. C. et al.: Clin Pharmacokinet., 41(3), 207-24, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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