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Carubicin

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SL-10244

Carubicin, >98%

CAS No. : [50935-04-1]

Synonyms : Carminomycin; Carminomicin I

IUPAC Name : (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,6,8,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione

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Chemical Properites
Mol. Formula :
C26H27NO10
Mol. Weight :
513.5
Appearance :
Solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : Carubicin is a compound of microbial origin. It effectively inhibits proliferation of VHL-defective (VHL−/−) CCRCC cells. Additionally, carubicin induces apoptosis through a mechanism that does not depend on p53 or hypoxia-inducible factor HIF2. Carubicin may be valuable for cancer research applications.

References : Woldemichael G. M. et al.: Cancer Res., 71(1), 134-142, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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