Cavalpha2delta‑1 / NET inhibitor

SI-6420

Cavα2δ‑1 / NET inhibitor, >98% (HPLC)

IUPAC Name : (S)-1-Methyl-4-(3-(3-(methylamino)-1-(thiophen-2-yl)propoxy)phenyl)-1,2,3,4-tetrahydro-5H-pyrido[2,3-e][1,4]diazepin-5-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a dual Cavα2δ‑1 / NET inhibitor, blocking the α2δ‑1 subunit of voltage‑gated calcium channels with K_i = 112 nM and inhibiting the norepinephrine transporter (NET) with K_i = 383 nM and IC₅₀ = 67 nM. It serves as a tool compound for pain research, targeting both Cavα2δ‑1‑mediated neuronal excitability and NET‑driven noradrenergic signaling.

References : Diaz L. J. et al.: J. Med. Chem., 64(4), 2167-2185, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.