CCT-251545

SI-7166

CCT-251545, >98% (HPLC)

CAS No. : [1661839-45-7]

IUPAC Name : 8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : CCT‑251545 is an orally bioavailable, potent CDK8/CDK19 inhibitor that suppresses WNT signaling with IC₅₀ = 5 nM in 7dF3 cells. It is a selective chemical probe for studying CDK8/19‑regulated transcription, showing strong cellular activity and suitability for cancer biology and pathway‑modulation research.

References : Mallinger A. et al.: J. Med. Chem., 58(4), 1717-35, 2015; Dale T. et al.: Nat Chem Biol., 11(12), 973-980, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.