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SI-7113

CDK-IN-9, >98% (HPLC)

CAS No. : [3031561-92-6]

IUPAC Name : N-(4-(1H-Pyrazol-1-yl)benzyl)-5-((2-aminoethyl)thio)-3-cyclobutyl-1H-pyrazolo[4,3-d]pyrimidin-7-amine

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Chemical Properites
Mol. Formula :
C21H24N8S
Mol. Weight :
420.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This potently inhibits CDKs and acts as a molecular glue to recruit CDK12 to DDB1, leading to cyclin K degradation. Its activity results in dephosphorylation of Rb and RNA Pol II, culminating in apoptosis.

References : Jorda R. et al.: J. Med. Chem., 65(13), 8881-8896, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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