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CDK2-IN-23

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SI-7552

CDK2-IN-23, >98% (HPLC)

CAS No. : [2488073-20-5]

IUPAC Name : 1-(4-(2-((1-(Cyclopropylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

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Chemical Properites
Mol. Formula :
C20H27F3N6O3S
Mol. Weight :
488.53
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This potently and selectively inhibits CDK2 at sub‑nanomolar concentrations (IC50= 0.29 nM) and demonstrates effective target engagement in CCNE1‑amplified mouse models. Its pharmacological profile makes it a valuable tool for investigating CDK2‑dependent oncogenic pathways.

References : Hummel J. R. et al.: J. Med. Chem., 67(4), 3112-3126, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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