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CE-245677

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SI-6371

CE-245677, >98% (HPLC)

CAS No. : [717899-97-3]

IUPAC Name : 1-(5-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxyphenyl)-3-(2,4-dichlorophenyl)urea

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Chemical Properites
Mol. Formula :
C24H22Cl2N6O3
Mol. Weight :
513.38
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : CE‑245677 reversibly inhibits Tie2 and TrkA/B with low‑nanomolar cellular potency (IC50 = 4.7 nM and 1 nM), providing a useful chemical probe for studying angiogenic and neurotrophic kinase signaling.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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