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Cefadroxil EP impurity D

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Cefadroxil EP impurity D, >98%

CAS No. : [144790-28-3]

Synonyms : Cefadroxil related compound D

IUPAC Name : (6R,7R)-7-((S)-2-Amino-2-(4-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Chemical Properites
Mol. Formula :
C16H17N3O5S
Mol. Weight :
363.39
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Cefadroxil, which is an oral broad-spectrum cephalosporin antibiotic that inhibits bacterial cell wall synthesis and enhances glutamate transporter-1 expression. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil is effective against various Gram-positive and Gram-negative bacteria and also provides analgesic effects for neuropathic pain.

References : Buck R. E. et al. Antimicrob Agents Chemother., 11(2), 324-30, 1977; Posada M. M. et al.: Pharm Res., 30(4), 1017-25, 2013; Hu Y. et al.: Biochem Pharmacol., 107, 81-90, 2016; Han C. J. et al.: Neuro Endocrinol Lett., 44(5), 309-320, 2023; Tan Z. et al.: Front Pharmacol., 12, 692741, 2021; Chisholm D. R. et al.: Antimicrob Agents Chemother., 30(1), 105-109, 1986; Chen X. et al.: Biochem Pharmacol., 131, 89-97, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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