Ceftiofur thiolactone

SL-10292

Ceftiofur thiolactone, >98%

CAS No. : [120882-23-7]

IUPAC Name : (Z)-2-(2-Aminothiazol-4-yl)-N-((5aR,6R)-1,7-dioxo-1,4,5a,6-tetrahydro-3H,7H-azeto[2,1-b]thieno[3,4-d][1,3]thiazin-6-yl)-2-(methoxyimino)acetamide

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Applications : This is an impurity of Ceftiofur, which is an inhibitor of cell wall synthesis that acts on bacterial penicillin-binding proteins (PBPs) and demonstrates notable anti-inflammatory properties in cases of endotoxemia. Ceftiofur bactericidal activity results from the suppression of peptidoglycan synthesis within bacterial cell walls, ultimately causing cell lysis. Furthermore, Ceftiofur impedes the activation of NF-κB and MAPKs, thereby diminishing the secretion of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6.

References : Salmon S. A. et al.: J. Vet Diagn Invest., 8(3), 332-336, 1996; Ci X. et al.: Biochem Biophys Res Commun., 372(1), 73-77, 2008; Ci X. et al.: Inflammation 31(6), 422-427, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.