CEP-40783

SI-6509

CEP-40783, >98% (HPLC)

CAS No. : [1437321-24-8]

Synonyms : RXDX-106

IUPAC Name : N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : CEP‑40783 selectively inhibits AXL (IC₅₀ = 7 nM) and c‑Met (IC₅₀ = 12 nM) with nanomolar potency and demonstrates good oral availability. Its dual‑target profile makes it suitable for probing AXL/MET‑dependent cancer pathways.

References : Sheila M. et al.: Molecular Targets and Cancer Therapeutics, 19-23, 2013, Boston M. A. Philadelphia (PA), AACR, Mol. Cancer Ther., 12(11), 2013; Jay F. et al.: Molecular Targets and Cancer Therapeutics, 19-23, 2013, Boston M. A. Philadelphia (PA), AACR, Mol. Cancer Ther., 12(11), 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.