Cephalothin sodium

SL-10258

Cephalothin sodium, >98%

CAS No. : [58-71-9]

Synonyms : Cefalotin sodium

IUPAC Name : Sodium (6R,7R)-3-(acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Applications : Cephalothin is a semi-synthetic cephalosporin and beta-lactam antibiotic. It inhibits AmpC class C β-lactamase (Ki = 0.32 µM) and binds penicillin-binding proteins, disrupting peptidoglycan cross-linking in bacterial cell walls. Cephalothin is active against various bacteria and is used in hematological and nephrotoxicity research.

References : Morandi S. et al.: Bioorg Med Chem., 16(3), 1195-205, 2008; Desiderio J. V. et al.: J. Infect Dis., 148(3), 563-70, 1983; Mobashery S. et al.: J. Biol Chem., 261(17), 7879-87, 1986; Cazenave J-P. et al.: Br. J. Haematol., 35(1), 135-52, 1977; Miraglia G. J. et al.: Antimicrob Agents Chemother., 3(2), 270-273, 1973; Dellinger P. et al.: Antimicrobial Agents and Chemotherapy 9(1), 172-178, 1976;
Goering R. V. et al.: J. Antibiot (Tokyo) 31(4), 363-72, 1978.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.